Southern California Users of Magnets


SCUM 2020! Today, Aug 29th

Host: Len Mueller (UC Riverside), Galia Debelouchina (UC San Diego), Ryan J. McCarty (UC Irvine)
Location: Online, on Zoom
Date: August 29th 2020

2020 Conference Schedule

8:55 AM Welcome
9:00 AM Marc Baldus, Utrecht University Cellular solid-state NMR: Recent progress and applications
9:45 AM Lyndon Emsley, EPFL DNP Enhanced Crystallography by Relay of Abundant Polarization
10:30 AM Matt Conley, UCR Generation of structurally defined sites on surfaces: Towards tailored heterogeneous catalysts.
11:00 AM Coffee break
11:15 AM Raphaele Clement, UCSB Short-range order and redox processes in rocksalt oxyfluoride cathodes approached by solid-state NMR and theory
11:45 AM Song-I Han, UCSB Role of electron spin dynamics and coupling network in dynamic nuclear polarization
12:15 PM Xiaoping Hu, UCR Imaging of Parkinson’s Disease with MRI
12:45 PM Lunch break
1:00 PM Online poster session
1:45 PM Ruben Elias, Deshmukh group, UCSD Study of Proline-rich Domain of Human ALIX by Solution NMR Spectroscopy
2:10 PM Tammy Dwyer, USD Studying “Alien” DNA: Structural and Functional Implications of Incorporating Modified and Unnatural Bases
2:40 PM James Kent, Marassi lab, SBP Studies of the Yersinia pestis outer membrane protein Ail in the bacterial cell envelope
3:05 PM Coffee break
3:15 PM Dylan Murray, UC Davis Assembly processes in low complexity sequence proteins: the case of tropomyosin intermediate filaments from Drosophila
3:45 PM Sang Ho Park, Opella group, UCSD NMR Characterization of the E and S Membrane Proteins of SARS-CoV-2

Thank you to our sponsor!

A big thank you to Cambridge Isotope Laboratories, (, for providing the poster session prizes!
Poster pic

We are also thankful to last year's sponsors Bruker Biospin, Americas, JEOL and Cambridge Isotope Labs. There was significantly less to sponsor this year, but we appreciate your past support and look forward to future meetings post pandemic.

2020 Online Poster Session

Poster pic
The Effect of Solvent Characteristics on the Amide Rotational Barrier in Nicotinamide and Picolinamide and the Free Energy of Activation (ΔG) for the Amide Rotational Barrier in Picolinamide.
Sam Shaffer, Mary Hatcher-Skeers group at Scripps College

Quantifying the ΔG for the amide rotational barrier in picolinamide and nicotinamide.

Poster pic
Multidimensional MAS-ssNMR of TDP43 Low-Complexity-Domain Fibrils
Blake D. Fonda, Murray Lab at UC Davis

Fibrils of the TDP43 low complexity domain, implicated in the pathology of neurodegenerative diseases, are studied using MAS-ssNMR to elucidate their structural features.

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MAS-ssNMR Techniques for Illuminating the intact Plant Cell Wall
Coyla Munson, Murray Lab at UC Davis

Resolving the in situ plant cell wall architecture by MAS-ssNMR continues to nail down future biomass applications, from food to fuel.

Poster pic
Decoding the allosteric nature of acyl carrier proteins
Terra Sztain, UC San Diego

Using NMR and MD, we demonstrate acyl carrier proteins can communicate the identity of sequestered substrates to parter enzymes allosterically, through protein-protein interactions, without the need for stochastic chain flipping.

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Can linker length and domain mobility control the interacting capabilities of multidomain proteins?
Pedro Diaz-parga, UC Merced

The length of the linker has an effect on the self-association of the multidomain protein ASC and its isoform ASCb.

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The Effect of Histone H4 K20 Methylation on Chromatin Compaction
Nesreen Elathram, UC San Diego

Using solid-state NMR tools to probe the dynamic interactions of H4K20 methylation in the chromatin environment at atomic resolution.

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Decoding protein protein interactions through a combinatorial NMR and computational protcol
Thomas Bartholow, UC San Diego

Utilizing NMR titrations and high resolution docking to study the protein protein interactions responsible for fatty acid biosynthesis' fidelity.

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Origin of the 29Si NMR Chemical Shift in R3Si-X and Its Relationship to the Formation of Silylium (R3Si+) Ions.
Winn Huynh, UC Riverside

Solid-state 29Si NMR and DFT analysis of the chemical shielding tensor in R3Si-X and R3Si+ reveal that the isotropic chemical shift is not related charge but rather the paramagnetic deshielding of σ(Si-R) --> σ*(Si-X)/p(Si).

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Non-Uniform Sampling and Preservation of the Spectral Knowledge.
Manpreet Kaler, UC Riverside

The work studies the efficacy of Fourier based NUS reconstruction approaches along with different sampling strategies to quantify the spectral knowledge.

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NMR Crystallography: Study of the Active Site of Tryptophan Synthase
Jacob Holmes, UC Riverside

Using NMR, X-ray crystallography, and computational chemistry to determine protonation states of the aminoacrylate intermediate.

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Design and characterization of a therapeutic pH-dependent membrane binding chimera protein
Christopher Randolph, UC Merced

The poster describes the design and characterization of a pH dependent membrane binding chimera.

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Sequence characterization and molecular modeling of clinically relevant variants of the SARS-CoV-2 main protease
Thomas J Cross, UC Irvine

Our group characterized naturally occurring mutations to the SARS-CoV-2 main protease and their subsequent effects on the active site to better inform robust inhibitor design.

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A Dual EPR/NMR Probe for a cryo-free ultralow temperature DNP system
Raj Chaklashiya, Han Group at UC Santa Barbara

A new probe with dual NMR and EPR detection capabilities at ultralow temperatures (~10K) at 6.905 T is designed, aiming to understand and optimize DNP experiments.

Poster pic
Structural insight into vitronectin’s role in age-related macular degeneration
Kyungsoo Shin, SBP Medical Discovery Institute

Using a combination of solution and solid-state NMR spectroscopy and other biophysical techniques to study the role of vitronectin in disease pathogenesis.

About SCUM

Southern California Users of Magnets (SCUM) is a welcoming group of magnetic spectroscopists from San Diego to Santa Barbara.

We hold an annual 1 day symposium/meeting, to bring together and build community among all folks interested in NMR, EPR, etc within our geographic area. Past participants have included researchers, scientists, students and professors (from private university, community colleges, CSUs, UCs, government, and industry), from just about every possible discipline.

We welcome all magnetic spectroscopists and students and would like to encourage the participation of individuals who's expertise loosely fit into magnetic/nuclear spectroscopy but are not explicitly mentioned.

Archive of past meeting programs here

The group is organized entirely by volunteers. Typically a research group from the region will volunteer hosting the meeting, using lecture halls and patios to provide meeting space. Meetings expenses have long been supported by generous sponsors, such as Cambridge Isotope Laboratories and Bruker, enabling an truly inclusive conference welcoming to the entire magnetic resonance community.

SCUM History

The initial concept, motivation, and drive behind SCUM came from Deniz Cizmeciyan who put together the very first SCUM in 1996.

I thought of creating a local NMR meeting when I was a Ph.D student at Penn State but since Penn State was pretty much in the middle of nowhere, quick access from neighboring cities would be difficult for a 1 day conference. Once I came to UCLA I acted upon creating a local NMR meeting. Our first meeting was at UCLA in July 1996, we had Miguel Garcia-Garibay and Julie Kornfield as speakers, our second meeting was at Caltech because I was then a post doc at Caltech, I can't remember our speakers but it might have been Dan Whitecamp and AJ Shaka, At our 3rd meeting at UCLA we had Alex Pines as one of our speakers, I remember Dieter Schaeffer speaking as well.

Professor Deniz Cizmeciyan, Mount Saint Mary's University

The group was first called LAME (Los Angeles Area Magnetic Experts), in the long tradition of NMR acronyms forming amusing words. In 1999, the meeting was held in San Diego county, so the name was updated to SCUM (Southern California Users of Magnets). In addition to Deniz Cizmeciyan, historic leadership was provided by Jane Strouse (UCLA), and Paul Shin (California State University Northridge).