|The Effect of Solvent Characteristics on the Amide Rotational Barrier in Nicotinamide and Picolinamide and the Free Energy of Activation (ΔG) for the Amide Rotational Barrier in Picolinamide.
Sam Shaffer, Mary Hatcher-Skeers group at Scripps College
Quantifying the ΔG for the amide rotational barrier in picolinamide and nicotinamide.
|Multidimensional MAS-ssNMR of TDP43 Low-Complexity-Domain Fibrils
Blake D. Fonda, Murray Lab at UC Davis
Fibrils of the TDP43 low complexity domain, implicated in the pathology of neurodegenerative diseases, are studied using MAS-ssNMR to elucidate their structural features.
|MAS-ssNMR Techniques for Illuminating the intact Plant Cell Wall
Coyla Munson, Murray Lab at UC Davis
Resolving the in situ plant cell wall architecture by MAS-ssNMR continues to nail down future biomass applications, from food to fuel.
|Decoding the allosteric nature of acyl carrier proteins
Terra Sztain, UC San Diego
Using NMR and MD, we demonstrate acyl carrier proteins can communicate the identity of sequestered substrates to parter enzymes allosterically, through protein-protein interactions, without the need for stochastic chain flipping.
|Can linker length and domain mobility control the interacting capabilities of multidomain proteins?
Pedro Diaz-parga, UC Merced
The length of the linker has an effect on the self-association of the multidomain protein ASC and its isoform ASCb.
| The Effect of Histone H4 K20 Methylation on Chromatin Compaction
Nesreen Elathram, UC San Diego
Using solid-state NMR tools to probe the dynamic interactions of H4K20 methylation in the chromatin environment at atomic resolution.
| Decoding protein protein interactions through a combinatorial NMR and computational protcol
Thomas Bartholow, UC San Diego
Utilizing NMR titrations and high resolution docking to study the protein protein interactions responsible for fatty acid biosynthesis' fidelity.
| Origin of the 29Si NMR Chemical Shift in R3Si-X and Its Relationship to the Formation of Silylium (R3Si+) Ions.
Winn Huynh, UC Riverside
Solid-state 29Si NMR and DFT analysis of the chemical shielding tensor in R3Si-X and R3Si+ reveal that the isotropic chemical shift is not related charge but rather the paramagnetic deshielding of σ(Si-R) --> σ*(Si-X)/p(Si).
| Non-Uniform Sampling and Preservation of the Spectral Knowledge.
Manpreet Kaler, UC Riverside
The work studies the efficacy of Fourier based NUS reconstruction approaches along with different sampling strategies to quantify the spectral knowledge.
| NMR Crystallography: Study of the Active Site of Tryptophan Synthase
Jacob Holmes, UC Riverside
Using NMR, X-ray crystallography, and computational chemistry to determine protonation states of the aminoacrylate intermediate.
|Design and characterization of a therapeutic pH-dependent membrane binding chimera protein
Christopher Randolph, UC Merced
The poster describes the design and characterization of a pH dependent membrane binding chimera.
|Sequence characterization and molecular modeling of clinically relevant variants of the SARS-CoV-2 main protease
Thomas J Cross, UC Irvine
Our group characterized naturally occurring mutations to the SARS-CoV-2 main protease and their subsequent effects on the active site to better inform robust inhibitor design.
|A Dual EPR/NMR Probe for a cryo-free ultralow temperature DNP system
Raj Chaklashiya, Han Group at UC Santa Barbara
A new probe with dual NMR and EPR detection capabilities at ultralow temperatures (~10K) at 6.905 T is designed, aiming to understand and optimize DNP experiments.
|Structural insight into vitronectin’s role in age-related macular degeneration
Kyungsoo Shin, SBP Medical Discovery Institute
Using a combination of solution and solid-state NMR spectroscopy and other biophysical techniques to study the role of vitronectin in disease pathogenesis.
Southern California Users of Magnets (SCUM) is a welcoming group of magnetic spectroscopists from San Diego to Santa Barbara.
We hold an annual 1 day symposium/meeting, to bring together and build community among all folks interested in NMR, EPR, etc within our geographic area. Past participants have included researchers, scientists, students and professors (from private university, community colleges, CSUs, UCs, government, and industry), from just about every possible discipline.
We welcome all magnetic spectroscopists and students and would like to encourage the participation of individuals who's expertise loosely fit into magnetic/nuclear spectroscopy but are not explicitly mentioned.
The group is organized entirely by volunteers. Typically a research group from the region will volunteer hosting the meeting, using lecture halls and patios to provide meeting space. Meetings expenses have long been supported by generous sponsors, such as Cambridge Isotope Laboratories and Bruker, enabling an truly inclusive conference welcoming to the entire magnetic resonance community.
The initial concept, motivation, and drive behind SCUM came from Deniz Cizmeciyan who put together the very first SCUM in 1996.
I thought of creating a local NMR meeting when I was a Ph.D student at Penn State but since Penn State was pretty much in the middle of nowhere, quick access from neighboring cities would be difficult for a 1 day conference. Once I came to UCLA I acted upon creating a local NMR meeting. Our first meeting was at UCLA in July 1996, we had Miguel Garcia-Garibay and Julie Kornfield as speakers, our second meeting was at Caltech because I was then a post doc at Caltech, I can't remember our speakers but it might have been Dan Whitecamp and AJ Shaka, At our 3rd meeting at UCLA we had Alex Pines as one of our speakers, I remember Dieter Schaeffer speaking as well.
The group was first called LAME (Los Angeles Area Magnetic Experts), in the long tradition of NMR acronyms forming amusing words. In 1999, the meeting was held in San Diego county, so the name was updated to SCUM (Southern California Users of Magnets). In addition to Deniz Cizmeciyan, historic leadership was provided by Jane Strouse (UCLA), and Paul Shin (California State University Northridge).